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【天工論壇第20期】Biosynthesis of modified tetrapyrroles: the pigments of life
  發布時間:2018-06-08    供稿部門:

  報告題目Biosynthesis of modified tetrapyrroles: the pigments of life

  報 告 人Martin James Warren 英國肯特大學生物科學學院生物化學系教授 

  報告時間613日(周三)10:00 

  報告地點:天津工業生物所B301階梯教室 

  報告摘要:The talk will concern the biosynthesis of modified tetrapyrroles, a group of molecules that include the haems, chlorophylls, sirohaem, coenzyme F430, haem d1 and the corrins (vitamin B12) within its membership. This molecular fraternity is often referred to as the “pigments of life” because of their associated strong colours and their involvement in all the major cellular processes of life including respiration, photosynthesis, methanogenesis and DNA synthesis. The molecular architectures of these metallo-cofactors represent some of the most complex small molecules made in cells, and their structures are reflected in equally beguiling and enigmatic biosynthetic pathways. Through the application of techniques such as molecular genetics, microbiology, enzymology and chemistry, coupled with a range of biophysical techniques including NMR, EPR and X-ray crystallography, we have been able to fundamentally advance the field of tetrapyrrole metabolism and understand the biosynthetic process. This has led to the discovery of new pathways for haem biosynthesis, the elucidation of the biochemical pathways for sirohaem, coenzyme F430, haem d1 and the anaerobic route for B12 biogenesis. This talk will reflect on some of the unprecedented molecular detail on the mechanism of the enzymes involved in the biosynthetic processes, which has generated new and novel insights into the chemical logic underpinning them.  

  報告人簡介Martin James Warren博士現任英國肯特大學生物科學學院生物化學系教授,英國生物技術與生物科學研究理事會任命委員會委員,生物化學學會、美國生物化學和分子生物學會、美國科學促進會會員以及英國皇家生物學會Fellow,英國生物化學會政策委員會委員。曾任肯特大學生物科學學院院長、英國生物技術與生物科學研究委員會教授Fellow、倫敦瑪麗王后大學生物科學學院生物化學教授、芬蘭科學院生物科學和環境研究理事會主席、芬蘭科學院合成生物學研究組長。 

  Warren教授研究領域涉及化學、生物學和進化學,是維生素B12等四吡咯化合物生物合成研究領域國際知名學者,具體研究內容包括色素分子如亞鐵血紅素、葉綠素、維生素B12、西羅血紅素、輔酶F430和血紅素d1的生物合成,尤其在亞鐵血紅素、維生素B12和輔酶F430合成途徑的解析方面做出了卓越貢獻,是最早利用合成生物學手段在大腸桿菌中解析并構建維生素B12從頭合成途徑的學者之一,其相關研究成果在Nature, Nature Chemical Biology, PNAS等著名期刊發表文章多篇,在四吡咯代謝研究領域擁有極大影響力。此外,他在研究鈷胺素參與丙二醇利用時發現了細菌的一種蛋白細胞器——細菌微區室,可使細胞產生新的形狀和形態并用于合成化學品,相關研究成果發表在Nature Chemical Biology,并同ZuvaSyntha公司合作開展利用細菌微區室技術合成大宗化學品。Warren教授承擔重要科研項目40余項,項目累計經費超過1500萬英鎊;受邀在相關科研機構及國際重要學術會議上做特邀報告50多次;至今累計在NatureLancetNature Chemical Biology PNASAngewandte Chemie International Edition Metabolic Engineering等著名雜志發表論文近100篇。 

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